Exocrine Pancreatic Insufficiency (EPI) Therapeutics Includes Pancreatic Enzyme Replacement Therapy Which Is A Safe And Effective Option Along With Enzyme Replacement Therapy And A Structured Follow-Up

 

Exocrine Pancreatic Insufficiency (EPI) Therapeutics Market

In a normal digestive process, ingested food is broken down in the stomach and then transported into the small intestine, where enzymes help to break it down further. This is done to make the food absorbable into the bloodstream and supply the body with all the nutrients it needs. The pancreas is one of the main exocrine glands and is a key organ in this process.

The pancreas secretes a variety of hormones and enzymes that play a critical role in digestion. Exocrine Pancreatic Insufficiency (EPI) Therapeutics also produces a large amount of sodium bicarbonate, which helps to maintain the acidity in the stomach and prevents dehydration.

Exocrine Pancreatic Insufficiency (EPI) Therapeutics function is impaired when a person has pancreatic insufficiency, which can be caused by chronic pancreatitis, pancreatic cancer or other conditions. Patients may experience symptoms of malabsorption syndrome, bloating and abdominal pain.

Diagnosis of pancreatic insufficiency requires a thorough medical history, a careful clinical examination and advanced tests to evaluate digestion, such as fecal fat quantification or the 13C-mixed triglycerides breath test. These tests are usually able to detect the presence of the disease if it is not already present.

Patients with pancreatic insufficiency have problems digesting their food, which can lead to a number of negative effects on their health. Exocrine Pancreatic Insufficiency (EPI) Therapeutics includes steatorrhea and weight loss, malnutrition-related complications such as osteoporosis, and reduced quality of life.

Treatment for EPI involves support to stop smoking and alcohol consumption, a diet consultation, pancreatic enzyme replacement therapy (PEERT) and a systematic follow-up. It is important to optimize the effectiveness of this treatment and ensure that the patient complies with the therapy, as noncompliance can reduce its efficacy.

Symptoms of pancreatic insufficiency include abdominal cramps, bloating and weight loss. They usually begin in the first few months after a diagnosis, it can occur at any time during the course of the condition.

Pancreatic enzyme replacement therapy is the gold standard for treating pancreatic insufficiency, and it has been shown to improve the nutritional status of patients with EPI and reduce steatorrhea and related symptoms. Along with a well-formulated and balanced diet, the use of enzymes can improve the nutritional status of patients with PEI by restoring the ability to absorb fat-soluble vitamins and increase absorption of protein-containing nutrients. This can result in better weight loss and less steatorrhea and gastric reflux, as well as improved nutrition and a lower risk of malnutrition-related morbidity and mortality.

AzurRx Biopharma, Inc. and Delpharm entered into a manufacturing agreement in April 2020, for the clinical drug product supply MS1819 therapy for exocrine pancreatic insufficiency.

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