CMI Express Blog

White Biotechnology White biotechnology, also known as industrial biotechnology, refers to the application of biotechnological processes and techniques to industrial processes for sustainable manufacturing. It harnesses microorganisms like bacteria, fungi, and algae and uses them to drive chemical and biological processes that can enable greener and more sustainable production. Applications of Industrial biotechnology The main applications of industrial biotechnology include production of biofuels, bioplastics, bio-based chemicals, food/feed additives and more through fermentation and other bioprocesses. Let us look at some of the important applications in detail: Biofuels Production One of the major applications of White Biotechnology  is in the production of biofuels like bioethanol and biodiesel as alternatives to fossil fuels. Through fermentation, microbes like yeast are able to efficiently convert various biomass feedstocks like sugarcane, corn, cellulosic materials into ...

Chemiluminescence Immunoassay Chemiluminescence immunoassay (CLIA) is a technique used for detecting and quantifying analytes such as antibiotics, hormones, vitamins, and proteins. It combines the specificity of immunoassay with the sensitivity and versatility of chemiluminescence detection. In a CLIA, the analyte of interest is labeled with an enzyme that generates a luminescent product during the enzymatic reaction. This light signal is then detected by a photomultiplier tube or a charge-coupled device (CCD) camera, allowing accurate quantification of the analyte present in the sample. Principle of Chemiluminescence Immunoassay The basic principle of CLIA involves an enzymatic reaction that produces light emission from a substrate. Horseradish peroxidase (HRP) and alkaline phosphatase (ALP) are two commonly used labeling enzymes. In an HRP-based CLIA, the analyte is tagged with HRP either directly or through an antigen-antibody complex. When HRP-catalyzed hydrogen peroxide oxidizes...

Global Antisense & RNAi Therapeutics The world of medicine and pharmaceuticals is constantly evolving, and one of the most exciting developments in recent years has been the rise of antisense and RNAi therapeutics. These groundbreaking treatments offer new possibilities for tackling diseases at the genetic level, providing hope for millions of patients worldwide. In this article, we'll explore the concept of global antisense and RNAi therapeutics, how they work, and their potential impact on the future of medicine. What Are Antisense & RNAi Therapeutics? Global Antisense & Rnai Therapeutics are innovative treatment strategies that target specific genetic sequences involved in the production of disease-causing proteins. By interfering with the process of protein synthesis, these therapies can potentially treat a wide range of genetic disorders, cancers, and other conditions. Antisense Therapeutics: These therapies use short, synthetic strands of nucleic ac...

Biosimilars Introduction to Biosimilars Biosimilars are biologic medical products that are developed to be similar to an already approved biologic drug, known as the reference product or originator biologic. Biosimilars contain similar active ingredients to the originator biologic and rely on similar manufacturing processes to that of the originator. However, biosimilars are not considered to be generics, as biologics tend to be much larger and more complex molecules than conventional small molecule drugs. Due to their complex nature, biologics cannot be perfectly replicated and thus biosimilars demonstrate certain acceptable differences from the reference product. Regulatory Approval Process for Biosimilars Regulatory agencies such as the U.S. Food and Drug Administration (FDA) have developed stringent approval pathways for biosimilars to demonstrate their similarity to the reference products. Biosimilars applicants must conduct analytical, animal, and clinical studies to prove bio...

Tissue Banking Introduction Tissue banking refers to the storage of human biological tissues for future medical applications. While still relatively new, tissue banking is becoming more widely adopted as a way to facilitate various medical procedures that rely on transplantable tissues. This article will explore the basics of tissue banking, its various applications in healthcare, the process of tissue donation and storage, as well as some of the ongoing initiatives to expand tissue banking services to more patients in need. What is Tissue Banking? Tissue Banking involves recovering tissues from donors during autopsy or surgery, processing them in approved facilities, and storing them for future use in medical procedures that require transplantable tissues. Some key aspects of tissue banking include: - Recovering tissues: Tissue banks work with organ procurement organizations and hospitals to recover tissues from deceased donors or living donors undergoing surgery. Common tissue...

Biodegradable Scaffolds Tissue engineering holds great promise for repairing damaged tissues and organs. One of the key components required for successful tissue engineering is the scaffold - a three-dimensional structure that supports cell growth and guides the regeneration of new tissue. Most conventional scaffolds used today are made from synthetic polymers that do not degrade in the body over time. However, biodegradable scaffolds offer several advantages that make them ideal for the future of regenerative medicine. What are biodegradable scaffolds? Biodegradable scaffolds are three-dimensional porous structures made from natural or synthetic polymers that can safely degrade in the body over time. Unlike permanent synthetic scaffolds, biodegradable scaffolds are designed to gradually break down as the body replaces them with newer tissue. This allows the scaffold structure and chemistry to change as the regenerating tissue matures and remodels. Some commonly used natural polymer...

  Bioelectronics Bioelectronics is revolutionizing healthcare by merging electronics and biology. Devices that interface directly with the human body have the potential to treat many medical conditions in novel ways. Here's a closer look at the exciting field of bioelectronics and what it may mean for the future of medicine. What is Bioelectronics? Bioelectronics refers to technologies that incorporate biological components with electronic components to interact with living systems. The goal is to monitor and modulate biological processes through engineered interfaces between biosystems and non-biological electronics. Some key characteristics of bioelectronic devices include: Interfacing electronics directly with neurons, tissues or organs in the body rather than externally. This allows for precise targeting of biological systems. Sensing biological signals and transmitting data wirelessly. Biosensors can detect biochemical markers, nerve impulses or muscle contractions....

Flow Cytometry Flow Cytometry has emerged as an invaluable tool in stem cell research, enabling scientists to characterize and isolate specific populations of stem cells with unprecedented precision. Stem cells, known for their remarkable regenerative capabilities and potential to differentiate into various cell types, hold great promise for regenerative medicine and understanding human development. Flow cytometry offers a comprehensive and efficient approach to analyze and separate stem cell populations based on their unique surface markers and functional properties. Characterizing stem cell populations is a crucial step in stem cell research, as it helps scientists understand their heterogeneity, functionality, and potential applications. allows researchers to identify and quantify specific cell surface markers associated with stem cells using fluorescently labeled antibodies. By analyzing the expression patterns of these markers, scientists can distinguish different types of stem ...

Influenza Vaccines Influenza, commonly known as the flu, is a highly contagious respiratory illness caused by influenza viruses. It can cause mild to severe illness and, in some cases, even lead to death. Each year, millions of people worldwide are affected by the flu, making it a significant public health concern. However, the availability of influenza vaccines plays a crucial role in protecting both individuals and the community as a whole. First and foremost, getting vaccinated against the flu is essential for personal protection. The influenza virus can lead to a range of symptoms, including fever, cough, sore throat, body aches, fatigue, and respiratory distress. By receiving the flu vaccine, individuals significantly reduce their chances of contracting the virus and experiencing these debilitating symptoms. Vaccination helps boost the immune system, enabling it to recognize and fight off the influenza virus more effectively. Moreover, influenza vaccines are particularly cruci...

Soft Tissue Repair  Soft Tissue Repair  that are producing discomfort and aberrant function are assessed and treated as part of soft tissue treatment. Ligaments, tendons, muscles, and fascia are examples of soft tissues. The body's natural process of replacing destroyed tissue with living tissue is known as soft tissue healing. The two steps of this procedure are regeneration and repair. Note: As the wound healing reaction "transitions" into the following stage of healing, there are no clearly defined boundaries between phases. The biomedical textile framework is used in a variety of devices, including heart valves, endovascular grafts, neurovascular stents, and load-sharing scaffolds. A material structure must be uniquely created based on application and biomimetic criteria using the appropriate textile-forming procedures. A crucial step in creating a drug-release fabric material is choosing the right material to meet a patient's requirements. Effective, precis...

Biopharmaceutical Contract Manufacturing  Biopharmaceuticals Contract Manufacturing . According to the report's focus, a contract manufacturing organization (CMO) is a business that performs contract work for other biopharmaceutical businesses, offering a full range of services from drug discovery to manufacture. Many businesses have had to hire new contract manufacturers or ingredient suppliers as a result of COVID-19's disruptions due to rising demand. Additionally, as  Biopharmaceutical Contract Manufacturing continues to grow, businesses that practice in-house manufacturing must deal with production challenges like a lack of knowledge and sophisticated equipment. A growing number of early-stage bio/pharma enterprises have emerged as a result of the maturation of biotechnology and the accessibility of outside investment. Due to their inability to establish reliable manufacturing processes, these businesses are acknowledged as core clients of CMOs. Since a large portio...

  Sterility Testing Sterility Testing and the development or validation of product-specific methods are critical steps in the drug development process. We have an established track record of supporting cell line, media, in-process and finished product testing for the pharmaceutical, biopharmaceutical and medical device industries. We also have a robust quality infrastructure to support CGMP testing according to USP and EP methods. The COVID-19 pandemic affected the growth of the Sterility Testing was a key tool for most pharmaceutical and biotechnology companies as they began to focus their research and development efforts on identifying leads that could diagnose and treat SARS-CoV-2 infection. The increase in COVID-19 cases prompted major companies and research institutions to look beyond conventional medicine or drugs, resulting in significant investment in research and development efforts by both private and public entities worldwide. Sterility Testing has grown tremendous...